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Purchase Femara (Letrozole) tablets online


How and where to order Letrozole (Femara) 2.5 mg tablets online:

Shop: CHEAP MEDS FOR SALE
Stores: PHARMA DOCTOR
Prices: from $0.70 per pill
Discount: 5% coupon: 5OFF
Forms: Femara (Letrozole) 2.5 mg tablets
Quantity: 30-270 pills
Type: Letrozole brand, Femara generic
Payment: Visa, Mastercard, AmEx, E-Check (ACH), Bitcoin
Delivery: Standard airmail and trackable courier service
Shipping: Worldwide, including USA, UK, Europe, Canada, Australia

Letrozole (trade names include Femara, Apo-Letrozole, Fempro, Accord Letrozole, Feofer, Letrozole Actavis, Letroz, Letrozole Teva, Losiral, Oreta, Sandoz Letrozole, Trozet) is an anticancer medication from aromatase inhibitors pharmacological group. This medicine is indicated for the treatment of hormonally-responsive local or metastatic breast cancer after surgery in postmenopausal women. It is also used for fertility, ovulation induction, in pretreatment for termination of pregnancy (in combination with misoprostol), gynecomastia, endometriosis, endometrial stromal sarcomas, uterine myoma, as a growth hormone, to promote spermatogenesis in male patients suffering from nonobstructive azoospermia. As anti cancer drug it works by lowering estrogen levels to prevent certain types of breast cancer.


Femara (Letrozole) 2.5 tablets


Related medications:

  • Aminoglutethimide (Cytadren)
  • Anastrozole (Arimidex)
  • Bromocriptine (Parlodel)
  • Butylscopolamine (Buscopan)
  • Cabergoline (Dostinex)
  • Capecitabine (Xeloda)
  • Clomiphene (Clomid)
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  • Desogestrel, Ethinyl Estradiol (Desogen)
  • Dydrogesterone (Duphaston)
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  • Estradiol (Estrace)
  • Estrogens conjugated (Premarin)
  • Exemestane (Aromasin)
  • Formestane (Lentaron)
  • Gestrinone (Dimetrose)
  • Hydroxyurea (Droxia)
  • Ibandronate (Boniva)
  • Imatinib (Gleevec)
  • Medroxyprogesterone (Cycrin)
  • Norethisterone (Aygestin, Norlutate)
  • Progesterone (Prometrium)
  • Raloxifene (Evista)
  • Sildenafil (Female Viagra)
  • Tadalafil (Female Cialis)
  • Tamoxifen (Nolvadex)
  • Vorozole (Vorozol)


    Pharmacological and medical categories:

  • Anticancer drugs
  • Antiestrogens
  • Antineoplastic agents
  • Fertility drugs
  • Hormonal chemotherapy
  • Medicines for the treatments of breast cancer
  • Nonsteroidal aromatase inhibitors
  • Oncology medications
  • Orally active aromatase inhibitors
  • Selective aromatase inhibitors
  • Women's health


    ATC codes:

  • L - Antineoplastic and immunomodulating agents
  • L02 - Endocrine therapy
  • L02B - Hormone antagonists and related agents
  • L02BG - Aromatase inhibitors
  • L02BG04 - Letrozole


    ICD-10 codes:

  • Malignant neoplasm of breast - C50
  • Malignant neoplasm of unspecified site of unspecified female breast - C50.919
  • Malignant neoplasm of corpus uteri - C54
  • Malignant neoplasm of endometrium - C54.1
  • Secondary malignant neoplasm of other and unspecified sites - C79
  • Secondary malignant neoplasm of breast - C79.81
  • Leiomyoma of uterus - D25
  • Other endocrine disorders - E34
  • Short stature due to endocrine disorder - E34.3
  • Postprocedural endocrine and metabolic complications and disorders, not elsewhere classified - E89
  • Symptomatic postprocedural ovarian failure - E89.41
  • Male infertility - N46
  • Organic azoospermia - N46.01
  • Azoospermia due to other extratesticular causes - N46.029
  • Hypertrophy of breast - N62
  • Endometriosis - N80
  • Complications following (induced) termination of pregnancy - O04
  • (Induced) termination of pregnancy with unspecified complications - O04.80
  • Estrogen receptor status - Z17
  • Estrogen receptor positive status [ER+] - Z17.0
  • Encounter for procreative management - Z31
  • Encounter for assisted reproductive fertility procedure cycle - Z31.83
  • Encounter for fertility testing - Z31.41


    Indications and usage:

    Femara (Letrozole) is an aromatase inhibitor indicated for:

  • Adjuvant treatment of postmenopausal women with hormone receptor positive early breast cancer.
  • Extended adjuvant treatment of postmenopausal women with early breast cancer who have received prior standard adjuvant tamoxifen therapy.
  • First and second-line treatment of postmenopausal women with hormone receptor positive or unknown advanced breast cancer.
  • Off-label uses for fertility, stimulation of ovulation.


    Dosage and administration:

    Letrozole (Femara) tablets are taken orally without regard to meals:

  • Recommended dose: 2.5.mg once daily.
  • Patients with cirrhosis or severe hepatic impairment: 2.5 mg every other day.


    Overdosage:

    Isolated cases of Femara (Letrozole) tablets overdose have been reported. In these instances, the highest single dose ingested was 62.5 mg or 25 tablets. While no serious adverse reactions were reported in these cases, because of the limited data available, no firm recommendations for treatment can be made. However, emesis could be induced if the patient is alert. In general, supportive care and frequent monitoring of vital signs are also appropriate. In single-dose studies, the highest dose used was 30 mg, which was well tolerated; in multiple-dose trials, the largest dose of 10 mg was well tolerated.

    Lethality was observed in mice and rats following single oral doses that were equal to or greater than 2,000 mg/kg (about 4,000 to 8,000 times the daily maximum recommended human dose on a mg/m2 basis); death was associated with reduced motor activity, ataxia and dyspnea. Lethality was observed in cats following single IV doses that were equal to or greater than 10 mg/kg (about 50 times the daily maximum recommended human dose on a mg/m2 basis); death was preceded by depressed blood pressure and arrhythmias.


    Dosage forms and strengths:

    Femara (Letrozole) 2.5 mg tablets.


    Contraindications:

  • Pregnancy
  • Known hypersensitivity to the active substance letrozole, or to any of the excipients


    Warnings and precautions:

  • Decreases in bone mineral density may occur. Consider bone mineral density monitoring.
  • Increases in total cholesterol may occur. Consider cholesterol monitoring.
  • Fatigue, dizziness, and somnolence may occur. Exercise caution when operating machinery.
  • Embryo-fetal toxicity: can cause fetal harm when administered to pregnant women. Obtain a pregnancy test in females of reproductive potential. Advise females of reproductive potential to use effective contraception.


    Adverse reactions, side effects:

    The most common adverse reactions of letrozole (greater than 20%) were hot flashes, arthralgia; flushing, asthenia, edema, arthralgia, headache, dizziness, hypercholesterolemia, sweating increased, bone pain, musculoskeletal pain.

    To report suspected side effects of Femara (Letrozole) tablets contact Novartis pharmaceutical company or your local FDA.


    Drug interactions:

  • Tamoxifen: coadministration of Femara and tamoxifen 20 mg daily resulted in a reduction of letrozole plasma levels of 38% on average (Study P015). Clinical experience in the second-line breast cancer trials (AR/BC2 and AR/BC3) indicates that the therapeutic effect of Femara therapy is not impaired if Femara is administered immediately after tamoxifen.
  • Cimetidine: a pharmacokinetic interaction study with cimetidine (Study P004) showed no clinically significant effect on letrozole pharmacokinetics.
  • Warfarin: an interaction study (P017) with warfarin showed no clinically significant effect of letrozole on warfarin pharmacokinetics.
  • Other anticancer agents: there is no clinical experience to date on the use of Letrozole (Femara) in combination with other anticancer agents.


    Use in specific populations:

    Lactation: advise not to breastfeed.


    Patient counseling information:

    Embryo-fetal toxicity

    Advise females of reproductive potential of the potential risk to a fetus and to use effective contraception during Femara therapy and for at least 3 weeks after the last dose. Advise females to contact their healthcare provider if they become pregnant, or if pregnancy is suspected, during treatment with letrozole tablets.

    Lactation

    Advise women not to breastfeed during Femara (Letrozole) treatment and for at least 3 weeks after the last dose.

    Infertility

    Advise females and males of reproductive potential of the potential for reduced fertility from Femara.

    Fatigue and dizziness

    Since fatigue and dizziness have been observed with the use of Letrozole (Femara) pills and somnolence was uncommonly reported, caution is advised when driving or using machinery.

    Bone effects

    Consideration should be given to monitoring bone mineral density.


    Pregnancy categories:

  • D - Australia
  • D - United States (Positive evidence of risk)


    Salts and other forms:

  • Letrozole Base


    Synonyms, international and chemical names:

  • Letrosol
  • Letrotsoli
  • Letrozol
  • Letrozolo
  • Letrozolum


    Brands, generics, trade names:

  • Apo-Letrozole - Apotex
  • Femara - Novartis
  • Fempro - Cipla
  • Feofer - Alna Biotech
  • Letroz - Sun Pharmaceutical Industries
  • Letrozole - Accord Healthcare, Actavis, Apotex, Mylan, Sun Pharmaceutical Industries, Teva
  • Letzol - VHB Life Sciences
  • Losiral - Neoraxis, Recalcine Laboratorios, Thuan Gia Pharmaceutical Trading
  • Oncolet - Biochem Pharmaceutical Industries
  • Oreta - Dr. Reddy's Laboratories
  • Sandoz Letrozole - Sandoz
  • Trozet - Fresenius
  • Zolet - United Biotech


    Here is a list of popular medications containing letrozole as a main active pharmaceutical ingredient; their trade names, forms, doses, companies - manufacturers, distributors, suppliers, researchers and developers:

    Trade name of the drug Pharmaceutical forms and doses Companies
    Femara
  • Tablets, Film-Coated; Oral; Letrozole 2.5 mg
  • Novartis
  • DKSH
  • Four Star
  • Zuellig Pharma
  • Fempro
  • Tablets, Film-Coated; Oral; Letrozole 2.5 mg
  • Cipla
  • Sandoz Letrozole
  • Tablets, Film-Coated; Oral; Letrozole 2.5 mg
  • Sandoz
  • Trozet
  • Tablets, Film-Coated; Oral; Letrozole 2.5 mg
  • Fresenius
  • Croma Medic
  • Dabur Pharmaceuticals
  • Medica Care



  • References:

  • Letrozole main article on Wikipedia: https://en.wikipedia.org/wiki/Letrozole
  • Letrozole compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Letrozole
  • Letrozole medicine on DrugBank: https://go.drugbank.com/drugs/DB01006
  • Letrozole FAQ on MedlinePlus (revised 01/15/2018): https://medlineplus.gov/druginfo/meds/a698004.html
  • Hormone therapy for breast cancer information on MedlinePlus (revised 09/24/2019): https://medlineplus.gov/ency/patientinstructions/000909.htm
  • Femara (Letrozole) tablets film-coated drug label on DailyMed (revised August 11, 2021): https://dailymed.nlm.nih.gov/dailymed/lookup...
  • Letrozole for sale on Pharma Doctor (revised September 2021): https://pharma-doctor.com/letrozole.html
  • Letrozole containing drugs on Drugs-About.com: https://drugs-about.com/ing/letrozole.html
  • Femara (Letrozole) 2.5 mg tablets for oral use official prescribing information from the U.S. FDA (revised 07/2017): https://www.accessdata.fda.gov/drugsatfda_docs/label...
  • Femara (Letrozole) tablets 2.5 mg prescribing information from Novartis pharmaceutical corporation (revised 05/2020): https://www.novartis.us/product/pi/pdf/Femara...
  • Femara (Letrozole) 2.5 mg tablets official website: https://www.femara.com/
  • Fempro (Femara generic) 2.5 mg tablets film-coated prescribing information from Cipla pharmaceutical company (revised 12/2017): https://www.ciplamed.com/content/fempro-tablets
  • Letrozole Sandoz film-coated tablets 2.5 mg consumer medicine information from NPS MedicineWise (revised May 2020): https://www.nps.org.au/assets/medicines/...
  • Femara (Letrozole) 2.5 mg film-coated tablets package information leaflet from Medicines.org.uk: https://www.medicines.org.uk/emc/files/pil.1029.pdf
  • Accord Letrozole 2.5 mg film-coated tablets package information leaflet from Medicines.org.uk: https://www.medicines.org.uk/emc/files/pil.6054.pdf

    Revised: September 2021
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